邓赟教授 中药化学
邓赟,二级教授、博士导师、必赢唯一官方网站院长;四川省学术和技术带头人、四川省有突出贡献的优秀专家、中药药效物质基础与创新中药发现四川省青年创新团队负责人,获四川省杰出青年学术技术带头人资助计划;世界中医药学会联合会道地药材多维评价专业委员会常务理事、世界中医药学会联合会中药化学专业委员会理事、四川省分析测试学会有机质谱专委会副主任委员。
个人联系方式
dengyun2000@hotmail.com
研究领域
长期从事中药化学教学、科研及科技管理工作。主要研究方向:应用化学生物学的前沿技术和方法开展中药药效物质、创新中药发现等领域的交叉创新研究。
专利与奖励
专利:
(1)一种冬虫夏草提取物在制备免疫检查点抑制剂上的用途,201910177206.4,第一
(2)一种冬虫夏草提取物及其制备方法,201910177207.9,第一
(3)一种新骨架大环混合肽聚酮化合物及其制备方法和用途,201810948742.5,第一
(4)伏康树中化合物的制备方法和用途,CN201610370856.7,第一
(5)同时测定地榆或地榆类制剂中没食子酸和地榆皂苷I含量的HPLC波长切换法,201611090970.0,第一
(6)一种胡芦巴总皂苷提取物的质量检测方法,CN104062372A,第一
(7)一种麦冬的综合提取利用技术,201010568007.5,第一
(8)一种PD-L1靶向肽药物偶联物及其合成方法和应用, CN202110179561.2,第二
(9)一种酸敏感靶多肽多柔比星偶联物及其合成方法和应用,CN202110179551.9.第二
奖励:
获国家教学成果奖二等奖1项,四川省科技进步三等奖2项,四川省哲学社会科学优秀成果三等奖1项。
出版信息
代表性论文:
(1)Qixuan Kuang, Qingzhou Li, Lirong Lei, Yumei Wang, Lijun Huang, Yifei Dai, Wan Peng, Mingzhi Zhang, Dong Wang, Yucheng Gu, Yun Deng*, Dale Guo*. Proliferatins suppress lipopolysaccharide-induced inflammation via inhibition of the NF-κB and MAPK signaling pathways. Bioorganic Chemistry, 2022, 124: 105810.
(2)Yao Che, Jirui Yang, Yi Zuo, Chaozheng Zhang, Yiru Pu, Qing Ren, Xiao Li, Yunqian Huang, Hui Huang, Huan Yang, Ouyang You, Xila Xia, Aiping Lu, Sanjun Shi*, Yun Deng*, Jun Lu*. Voacamine is a novel inhibitor of EGFR exerting oncogenic activity against colorectal cancer through the mitochondrial pathway, PHARMACOLOGICALRESEARCH, 2022,184:106415. DOI:10.1016/j.phrs.2022.106415.
(3)Lei, Li-Rong,Gong, Lei-Qiang,Jin, Meng-Ying,Wang, Rui,Liu, Ran,Gao, Jing,Liu, Meng-Dan,Huang, Li,Wang, Guang-Zhi,Wang, Dong*,Deng, Yun*,Research advances in the structures and biological activities of secondary metabolites from Talaromyces,FRONTIERS IN MICROBIOLOGY,AUG 19,2022,VL 13,DI 10.3389/fmicb.2022.984801
(4)Shen, Yurong,Yang, Guanyu,Huang, Wei,Shaginian, Alex,Lin, Qian,Wan, Jinqiao*,Li, Jin,Deng, Yun*,Liu, Guansai*,Photoredox Deaminative Alkylation in DNA-Encoded Library Synthesis,ORGANIC LETTERS,APR 15,2022,VL 24,IS 14,2650-2654,DI 10.1021/acs.orglett.2c00697.
(5)Xue-Yan Huo, Xue-Yan Huo; Li-Rong Lei; Wen-Xiu Guo; Yun-Jie Hu; Qi-Xuan Kuang; Meng-Dan Liu; Wan Peng; Yi-Fei Dai; Dong Wang; Yu-Cheng Gu; Da-le Guo*; Yun Deng*,Trichodimerol inhibits inflammation through suppression of the nuclear transcription factor-kappaB/NOD-like receptor thermal protein domain associated protein 3 signaling pathway,Frontiers in Microbiology, 2022, 23 August , 10.3389/fmicb.2022.999996
(6)Qixuan Kuang, Yan Luo, Lirong Lei, Wenxiu Guo, Xinai Li., Yumei Wang, Xueyan Huo, Mengdan Liu, Qi Zhang, Dan Feng, Lijun Huang, Dong Wang, Yucheng Gu, Yun Deng*, Dale Guo*. Hydroanthraquinones from Nigrospora sphaerica and their anti-inflammatory activity uncovered by transcriptome analysis. Journal of Natural Products, 2022, doi: 10.1021/acs.jnatprod.1c01141.
(7)Qixuan Kuang, Lirong Lei, Qingzhou Li, Wan Peng, Yumei Wang, Yifei Dai, Dong Wang, Yun Deng*, Dale Guo*. Investigation of the anti-inflammatory activity of fusaproliferin analogues guided by transcriptome analysis. Frontiers in Pharmacology, 2022, 13: 881182.
(8)Yurong Shen, Guanyu Yang, Wei Huang, Alex Shaginian, Qian Lin, Jinqiao Wan*, Jin Li, Yun Deng*, Guansai Liu*. Photoredox deaminative alkylation in DNA-encoded library synthesis. Organic Letters, 2022, 24(14):
(9)Lijun Huang#, Yumei Wang#, Leiqiang Gong, Chao Hu, Yu Gui, Chen Zhang, Xue Tan, Xiankuo Yu, Yile Liao, Yan Luo, Yuqin Tang, Yifei Dai, Yun Deng*, Dong Wang*, Dale Guo*. N-acetyldopamine dimer attenuates DSS-induced ulcerative colitis by suppressing NF-κB and MAPK pathways. Frontiers in Pharmacology, 2022, 13: 842730.
(10)Zhang, Yue#; Luo, Huadong#; Ma, Huiyong; Wan, Jinqiao*; Ji, Yue; Shaginian, Alex; Li, Jin; Deng, Yun*; Liu, Guansai*, On-DNA Derivatization of Quinoxalin-2-ones by Visible-Light-Triggered Alkylation with Carboxylic Acids, Bioconjugate Chemistry, 2021, 32(8): 1576-1580.
代表性著作、教材:
主编、副主编专著教材8部,包括主编 “十三五”行业规划教材《仪器分析》、“十二五”规划教材《仪器分析》;副主编《泰国中药质量标准》、《中国临床药物大辞典-中药饮片卷》、《中国临床药物大辞典-中药成方制剂卷:全两卷》、《系统中药学》、《波谱分析》等。获国家教学成果奖二等奖1项,四川省科技进步三等奖2项,四川省哲学社会科学优秀成果三等奖1项。
科研活动
主持国家自然基金重点项目(联合基金)、四川省青年创新团队等多项课题,提出中药活性成分迭代垂钓技术、DNA编码化合物技术应用于中药作用靶点发现等新方法,发现了多个中药活性成分。发表学术论文140余篇,其中SCI收录70余篇。申请发明专利30项,授权21项。