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博士研究生导师

郭力教授 中药化学

个人简介

郭力,博士,教授,博士生导师,国务院特殊津贴专家,四川省学术和技术带头人,四川省中医药学术和技术带头人,四川省有突出贡献优秀专家。长期从事中药化学成分与中药质量标准化研究,探索和阐明中药药效物质基础,重点围绕川产道地药材附子、川乌、石斛、熊胆粉、鹿茸等品种的化学成分、炮制、配伍、药理活性等多方面展开研究,对建立其质量控制体系进行了积极探索。研发新药及健康产品10余项,主持多项科研课题,授权专利10余项,出版专著20余部,发表论文百余篇,其中SCI论文70余篇,包括《Biomaterials》、《European Journal of Medicinal Chemistry》、《MICROCHEMICAL JOURNAL》《International Journal of Biological Macromolecules》等著名期刊;培养硕博研究生60余名,其中在读硕博士10余名。



个人联系方式

 guoli@cdutcm.edu.cn


研究领域

长期从事中药化学成分与中药质量标准化研究,探索和阐明中药药效物质基础,重点围绕川产道地药材附子、川乌、石斛、熊胆粉等品种的化学成分、炮制、配伍、药理活性等多方面研究,对建立其质量控制体系进行了积极探索。



专利与奖励

专利(不超过10项):

授权专利10余项

奖励(不超过10项):

(1) 郭力,参附注射液品质控制与产业化关键技术应用,国家科技部,国家科学技术进步奖,二等奖,2013

(2) 郭力,乌头类有毒中药安全性评价模式的建立与示范,中国医疗保健国际交流促进会,华夏医学科技奖,二等奖,2013

(3) 郭力,参附注射液的基础、临床与产业化关键问题研究,四川省人民政府,四川省科技进步奖,一等奖,2012

(4) 郭力,附子的系统研究与开发应用,四川省人民政府,四川省科技进步奖,一等奖,2010

(5) 郭力,病证结合动物模型创制与中药复方有效部位创新中药寻找模式研究,四川省人民政府,四川省科技进步奖,一等奖,2006


出版信息

代表性论文(不超过10项):

(1)Yuan Minghao#, Gong Sheng, Liu Yushi, Li Xiaohong, Li Meifeng, Zeng Dafu, Li Jianjiang, Guo Yiping, Guo Li*; Rapid discrimination of the authenticity and geographical origin of bear bile powder using stable isotope ratio and elemental analysis, Anal Bioanal Chem, 2023, 415(2):345-356.

(2)Lei Kelu#, Yuan Minghao, Li Sihui, Zhou Qiang, Li Meifeng, Zeng Dafu, Guo Yiping*, Guo Li*; Performance evaluation of E-nose and E-tongue combined with machine learning for qualitative and quantitative assessment of bear bile powder, Anal Bioanal Chem, 2023, 415(17): 3503-3513.

(3)Sheng Gong#, Minghao Yuan, Yushi Liu, Ya’ning Zhu, Chenjuan Zeng, Cheng Peng, Guo Li*; Application of stable isotopes with machine learning techniques for identifying Aconiti Lateralis Radix Praeparata (Fuzi) geographical origins, Microchemical Journal, 2023,183:108002.

(4)Li Meifeng#, Zhang Xiaoning*, Zhang Yifeng, Shao Xiaoqing, Liu Honglu, Guo Li*, Wang, Cunfeng*; Study on the characterization of polysaccharide from Tuber sinense and its desensitization effect to in vivo, Journal of Functional Foods, 2022, 91:105028.

(5)Song Jiawen#, Liu Yushi#, Guo Yurou, Zhong Wenxiao, Guo Yiping, Guo Li*; Nano-Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti-Tumor Effects, Int J Mol Sci. 2022, 23(12):6858.

(6)Xiao Haijun#; Guo Yiping#; Liu Hongmei; Liu Yushi; Wang Yumin; Li Changqing; Jaroslav Císař; David Škoda; Ivo Kuřitka, Guo Li*; Vladimír Sedlaříkp*; Structure-based design of charge-conversional drug self-delivery systems for better targeted cancer therapy, Biomaterials, 2020, 232.

(7)Li He#; Qian Su#; Lan Bai#; Meifeng Li; Juanru Liu; Xiaomei Liu; Cunyan Zhang; Zhongliang Jiang; Jun He; Jianyou Shi*; Shan Huang*, Guo Li*; Recent research progress on natural small molecule bibenzyls and its derivatives in Dendrobium species, European Journal of Medicinal Chemistry, 2020, 112530.

(8)Liu Yushi#, Yuan Minghao, Zhang Cunyan, Liu Hongmei, Liu Juanru, Wei Ailing, Ye Qiang, Zeng Bin, Li Meifeng, Guo Yiping*, Guo Li*. Puerariae Lobatae radix flavonoids and puerarin alleviate alcoholic liver injury in zebrafish by regulating alcohol and lipid metabolism. Biomed Pharmacother. 2021; 134:111121.

(9)Liu Hongmei#, Yuan Minghao, Liu Yushi, Guo Yiping, Xiao Haijun, Guo Li*, Liu F. Self-Monitoring and Self-Delivery of Self-Assembled Fluorescent Nanoparticles in Cancer Therapy. Int J Nanomedicine. 2021; 16:2487-99.

(10) Guo Yiping#, Liu Hongmei#, Xiao Haijun#, Yuan Minghao, Liu Yushi, Sedlarik Vladimír, Chin Wei-Chin, Liu Juanru, Guo Li*, Li Changqing. Self-assembled Camptothecin derivatives - Curcuminoids conjugate for combinatorial chemo-photodynamic therapy to enhance anti-tumor efficacy. J Photochem Photobiol B. 2021; 215:112124.


科研活动

科研课题(不超过10项):

1 国家科技部,国家重点研发项目子课题,高品质道地药材中药材附子规模化种植及精准扶贫示范研究,主持

2 四川省科技厅,四川省科技基础条件平台项目,四川省中药化合物资源共享平台,主持

3 横向课题,熊胆、梅花鹿系列产品研究开发,成都晶博生物科技有限责任公司,主持

4 成都市药品检验研究院,国家药品监督管理局中药材质量监督评价重点实验室开放课题,以陈皮为例,用于检测黄曲霉毒素B1的纳米探针研究,主持

5 达州市科技局达州市对外合作项目,达州虎杖质量评价及资源综合利用研究,主持


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