黄胜雄教授 中药资源学
博士，教授，硕士和博士研究生导师，药学院。中国生物化学与分子生物学会酶学专业委员会委员，云南省植物学会理事、川北生物医药产业技术研究院专家委员会委员、四川文理学院特色植物开发研究重点实验室学术委员会委员。
主要从事传统中药和植物内生菌中活性天然产物的发现和生物合成途径解析及合成生物学研究；利用有机合成和生物合成手段创造天然产物的结构多样性并探讨其与药理活性间的构效关系，进而进行创新药物研发。作为项目负责人先后承担国家自然基金、国家重点研发计划子课题及省级科研课题10余项。部分科研成果以通讯或第一作者发表在Nat Commun、PNAS、JACS、Angew Chem、Chem Sci、ACS Catalysis和Org Lett等杂志上。共发表研究论文100余篇，所有文章的引用超过4000次，部分研究成果作为研究热点被评述。2019年入选中共中央组织部国家“万人计划”科技创新领军人才、2015年获得国家基金委“优秀青年基金”支持、2014年入选中组部“青年千人计划”。
研究领域
中药活性成分的生物合成解析和合成生物学创制
出版信息
(1) Yijun Yan, Zhiyin Yu, Wei Zhong, Xiaodong Hou, Qiaoqiao Tao, Minhang Cao, Li Wang, Xiaofeng Cai, Yijian Rao, Sheng-Xiong Huang*. Characterization of multifunctional and non-stereoselective oxidoreductase RubE7/IstO, expanding the functional diversity of the flavoenzyme superfamily [J]. Angewandte Chemie-International Edition, 2022, doi.org/10.1002/anie.202200189.
(2) Jian-Ping Huang, Chengli Fang, Xiaoyan Ma, Li Wang, Jing Yang, Jianying Luo, Yijun Yan, Yu Zhang*, Sheng-Xiong Huang*. Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation [J]. Nature Communications 2019, 10, 4036.
(3) Yijun Yan, Jing Yang, Zhiyin Yu, Mingming Yu, Ya-Tuan Ma, Li Wang, Can Su, Jianying Luo, Geoff P. Horsman, Sheng-Xiong Huang*. Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids [J]. Nature Communications 2016, 7, 13083.
(4) Yijun Yan, Jing Yang, Li Wang, Dongdong Xu, Zhiyin Yu, Xiaowei Guo, Geoff P. Horsman, Shuangjun Lin, Meifeng Tao, Sheng-Xiong Huang*. Biosynthetic access to the rare antiarose sugar via an unusual reductase-epimerase [J]. Chemical Science 2020, 11, 3959–3964.
(5) Jian-Ping Huang, Yong-Jiang Wang, Tian Tian, Li Wang, Yijun Yan, Sheng-Xiong Huang*. Tropane alkaloid biosynthesis: a centennial review [J]. Natural Product Reports 2021, 38, 1634–1658.
(6) Li Wang, Jing Yang, Jian-Ping Huang, Jie Li, Jianying Luo, Yijun Yan, Sheng-Xiong Huang*. Bisaspochalasins A−C: Three cytochalasan homodimers with highly fused ring system from an endophytic Aspergillus flavipes [J]. Organic Letters 2020, 22, 7930–7935.
(7) Fei Qiu, Yijun Yan, Junlan Zeng, Jian-Ping Huang, Lingjiang Zeng, Wei Zhong, Xiaozhong Lan, Min Chen, Sheng-Xiong Huang*, Zhihua Liao*. Biochemical and metabolic insights into hyoscyamine dehydrogenase [J]. ACS Catalysis 2021, 11, 2912–2924.
(8) Ke-Na Feng, Yan-Long Yang, Yu-Xing Xu, Yue Zhang, Tao Feng, Sheng-Xiong Huang*, Ji-Kai Liu*, Ying Zeng*. A hydrolase-catalyzed cyclization forms the fused bicyclic β-lactone in vibralactone [J]. Angewandte Chemie-International Edition 2020, 59, 7209–7213.
(9) Li Wang, Jing Yang, Ling-Mei Kong, Jun Deng, Zijun Xiong, Jian-Ping Huang, Jianying Luo, Yijun Yan, Yikao Hu, Xiao-Nian Li, Yan Li, Yong Zhao*, Sheng-Xiong Huang*. Natural and semisynthetic tigliane diterpenoids with new carbon skeletons from Euphorbia dracunculoides as a Wnt signaling pathway inhibitor [J]. Organic Letters 2017, 19, 3911–3914.
(10) Yijun Yan, Ya-Tuan Ma, Jing Yang, Geoff P. Horsman, Dan Luo, Xu Ji, Sheng-Xiong Huang*. Tropolone ring construction in the biosynthesis of rubrolone B, a cationic tropolone alkaloid from endophytic Streptomyces [J]. Organic Letters 2016, 18, 1254–1257.